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Hyperlactatemia: Likelihood Ratios

Introduction: From eMedicine: "The normal blood lactate concentration in unstressed patients is 1-0.5 mmol/L. Patients with critical illness can be considered to have normal lactate concentrations of less than 2 mmol/L. Hyperlactatemia is defined as a mild-to-moderate persistent increase in blood lactate concentration (2-5 mmol/L) without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >4-5 mmol/L) in association with metabolic acidosis." [http://emedicine.medscape.com/article/768159-overview]

See also Mortality in Sepsis, which is correlated with rising lactate.

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Tags: Metabolic Tag this Diagnosis.

The likelihood ratios of findings for Hyperlactatemia are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Good Positive Likelihood Ratio
FindingResult +LR-LR
[ + ] Anion Gap + 0 - 2.20.9
Poorly Diagnostic Findings
FindingResult +LR-LR
[ + ] Albmuin-Corrected Anion Gap + 0 - 1.60.8
[ + ] Base Deficit + 0 - 1.40.7