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Hyperlactatemia: Sensitivity and Specificity

Introduction: From eMedicine: "The normal blood lactate concentration in unstressed patients is 1-0.5 mmol/L. Patients with critical illness can be considered to have normal lactate concentrations of less than 2 mmol/L. Hyperlactatemia is defined as a mild-to-moderate persistent increase in blood lactate concentration (2-5 mmol/L) without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >4-5 mmol/L) in association with metabolic acidosis." [http://emedicine.medscape.com/article/768159-overview]

See also Mortality in Sepsis, which is correlated with rising lactate.

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Tags: Metabolic Tag this Diagnosis.

The sensitivity and specificity of findings for Hyperlactatemia are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Anion Gap + 0 - 14.5%93.5%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Albmuin-Corrected Anion Gap + 0 - 32.3%79.7%
[ + ] Base Deficit + 0 - 64.7%52.9%