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Hyperaldosteronism: Sensitivity and Specificity

Introduction: Also known as Conn's syndrome, this is an endocrine cause of hypertension, resulting either from an adrenal adenoma or bilateral adrenal hyperplasia. The high aldosterone levels cause retention of sodium and loss of potassium and hydrogen ions. There is also secondary suppression of renin levels.

Blood tests must be done off of any drugs that could interfere with the renin-angiotensin-aldosterone axis.

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Tags: Endocrine Tag this Diagnosis.

The sensitivity and specificity of findings for Hyperaldosteronism are listed below. See the left navigation bar to change the display.

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Finding SensitivitySpecificity Comments, Study
Aldosterone to Renin Ratio
Duplicate Edit
96.5%100%

0900 h recumbent, cutoff of 35

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Aldosterone to Renin Ratio
Duplicate Edit
100%100%

after 2L saline infusion, cutoff of 18.5

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Aldosterone to Renin Ratio
Duplicate Edit
96.5%88.9%

1300 hr, ambulatory, cutoff of 13.1

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Hypokalemia Edit No accuracy specified.

Some recommend screening all hypertensive patients with hypokalemia for hyperaldosteronism.

Study: no study specified.

Plasma Aldosterone
Duplicate Edit
93%77.8%

0900 h, recumbent, cutoff of 11.9

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Plasma Aldosterone
Duplicate Edit
100%76.5%

after 2L normal saline infusion, cutoff of 5.1

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Plasma Renin Activity Edit 91.2%88.9%

0900 h, recumbent, cutoff of 0.32

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077