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Hyperaldosteronism: Sensitivity and Specificity

Introduction: Also known as Conn's syndrome, this is an endocrine cause of hypertension, resulting either from an adrenal adenoma or bilateral adrenal hyperplasia. The high aldosterone levels cause retention of sodium and loss of potassium and hydrogen ions. There is also secondary suppression of renin levels.

Blood tests must be done off of any drugs that could interfere with the renin-angiotensin-aldosterone axis.

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Tags: Endocrine Tag this Diagnosis.

The sensitivity and specificity of findings for Hyperaldosteronism are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Aldosterone to Renin Ratio + 0 - 100%100%
[ + ] Aldosterone to Renin Ratio + 0 - 96.5%100%
[ + ] Aldosterone to Renin Ratio + 0 - 96.5%88.9%
[ + ] Plasma Renin Activity + 0 - 91.2%88.9%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Plasma Aldosterone + 0 - 100%76.5%
[ + ] Plasma Aldosterone + 0 - 93%77.8%
Findings With Unspecified Accuracy
FindingResult SensitivitySpecificity
[ + ] Hypokalemia No accuracy specified.