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Good Positive and Negative Likelihood Ratios

Findings With Unspecified Accuracy

Hyperaldosteronism: Likelihood Ratios

Introduction: Also known as Conn's syndrome, this is an endocrine cause of hypertension, resulting either from an adrenal adenoma or bilateral adrenal hyperplasia. The high aldosterone levels cause retention of sodium and loss of potassium and hydrogen ions. There is also secondary suppression of renin levels.

Blood tests must be done off of any drugs that could interfere with the renin-angiotensin-aldosterone axis.

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Tags: Endocrine Tag this Diagnosis.

The likelihood ratios of findings for Hyperaldosteronism are listed below. See the left navigation bar to change the display.

Good Positive and Negative Likelihood Ratios

Finding +LR-LR Comments, Study
Aldosterone to Renin Ratio
Duplicate Edit
inf0

0900 h recumbent, cutoff of 35

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Aldosterone to Renin Ratio
Duplicate Edit
inf0

after 2L saline infusion, cutoff of 18.5

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Aldosterone to Renin Ratio
Duplicate Edit
8.70

1300 hr, ambulatory, cutoff of 13.1

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Plasma Aldosterone
Duplicate Edit
4.30

after 2L normal saline infusion, cutoff of 5.1

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Plasma Renin Activity Edit 8.20.1

0900 h, recumbent, cutoff of 0.32

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Plasma Aldosterone
Duplicate Edit
4.20.1

0900 h, recumbent, cutoff of 11.9

Study: J Clin Endocrinol Metab. 2005 Jan;90(1):72-8. PMID: 15483077

Findings With Unspecified Accuracy

Finding +LR-LR Comments, Study
Hypokalemia Edit No accuracy specified.

Some recommend screening all hypertensive patients with hypokalemia for hyperaldosteronism.

Study: no study specified.