Hydatidiform Mole: Sensitivity and Specificity

Introduction: Hydatidiform mole is a benign neoplasm of trophoblastic tissue. It is thought to occur when a sperm fertilizes an empty egg.

Prevalence

Population / Calculator	Prevalence	Comments / Study / Link
All pregnancies	0.1%	UpToDate http://www.utdol.com/online/content/topic.do?topicKey=gyne_onc/7618
Pregnancies in women with previous molar pregnancy	1%	UpToDate http://www.utdol.com/online/content/topic.do?topicKey=gyne_onc/7618
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The sensitivity and specificity of findings for Hydatidiform Mole are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)


Finding	Result	Sensitivity	Specificity
[ + ] Transvaginal US	+ 0 -	44%	74%
misdiagnosis usually from attributing symptoms to missed or incomplete abortion Study: Ultrasound Obstet Gynecol. 2006 Jan;27(1):56-60. PMID 16273594