Human Immunodeficiency Virus: Likelihood Ratios

Introduction: None written.

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Prevalence

Population / Calculator	Prevalence	Comments / Study / Link
1000	2%
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The likelihood ratios of findings for Human Immunodeficiency Virus are listed below. See the left navigation bar to change the display.

Good Positive and Negative Likelihood Ratios

Finding	+LR	-LR	Comments, Study
Blood Rapid Antibody Test	997	0	from whole blood Study: AIDS. 2006 Aug 1;20(12):1655-1660. PMID 16868447
Western Blot	331	0	'window period' of seronegativity is approximately 3-6 weeks in newest-generation assays. p24 antigen should be sensitive in this timeframe. Study: CDC Survey, cited in UpToDate http://www.utdol.com/online/content/topic.do?topicKey=hiv_infe/5102
HIV RNA PCR	33.3	0	All false positives had levels < 2000 copies/ml. Study: Ann Intern Med 2001 Jan 2;134(1):25-9. PMID 11187417
Oral Rapid Antibody Test	32.2	0	aka "OraSure" or "OraQuick" . Another study found sens = 99.1% and spec = 99.6%. Study: sens: JAMA 1997 Jan 15;277(3):254-8. PMID 9005276 spec: Ann Intern Med. 2008 Aug 5;149(3):153-60. PMID 18678842 alternative: AIDS. 2006 Aug 1;20(12):1655-1660. PMID 16868447
p24 Antigen	inf	0.1	Study: Ann Intern Med 2001 Jan 2;134(1):25-9. PMID 11187417

Good Positive Likelihood Ratio

Finding	+LR	-LR	Comments, Study
Genital Ulcer	8	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Swollen Lymph Nodes	5.5	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Weight loss	5.3	0.8	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Emesis	4.3	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Diarrhea	4	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Arthralgia	4	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Fever	3.3	0.7	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Oral ulcer	3.3	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
nausea	3.3	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Night Sweats	3	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Fatigue	2.8	0.8	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
Headache	2	0.9	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954
genital wart	2	1	Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954

Poorly Diagnostic Findings

Rash

1.5

Study: Wood, E., Kerr, T., Rowell, G., Montaner, J. S. G., Phillips, P., Korthuis, P. T., & Simel, D. L. (2014). Does This Adult Patient Have Early HIV Infection? JAMA, 312(3), 278. doi:10.1001/jama.2014.5954

Findings With Unspecified Accuracy

Thrush

No accuracy specified.

Study: no study specified.

Salivary gland enlargement, bilateral

No accuracy specified.

Study: no study specified.