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Hirschsprung's Disease: Sensitivity and Specificity

Introduction: Hirschsprung's disease, technically congenital aganglionic megacolon, results from incomplete migration of the neural crest precursor cells that are the progenitors of the ganglion cells that innervate the large intestine. Thus, this disease is manifested by lack of intestinal motility distal to a certain point.

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Tags: Congenital Gastrointestinal Problem Tag this Diagnosis.

The sensitivity and specificity of findings for Hirschsprung's Disease are listed below. See the left navigation bar to change the display.

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Finding SensitivitySpecificity Comments, Study
Anorectal Manometry Edit 83%93%

Study: J Pediatr. 2005 Jun;146(6):787-92 PMID: 15973319

Contrast enema Edit 76%97%

Study: J Pediatr. 2005 Jun;146(6):787-92 PMID: 15973319

Rectal suction biopsy Edit 93%100%

Study: J Pediatr. 2005 Jun;146(6):787-92 PMID: 15973319