Hirschsprung's Disease: Likelihood Ratios

Introduction: Hirschsprung's disease, technically congenital aganglionic megacolon, results from incomplete migration of the neural crest precursor cells that are the progenitors of the ganglion cells that innervate the large intestine. Thus, this disease is manifested by lack of intestinal motility distal to a certain point.

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Tags: Congenital Gastrointestinal Problem Tag this Diagnosis.

The likelihood ratios of findings for Hirschsprung's Disease are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Good Positive and Negative Likelihood Ratios
Finding	Result	+LR	-LR
[ + ] Rectal suction biopsy	+ 0 -	inf	0.1
Study: J Pediatr. 2005 Jun;146(6):787-92 PMID: 15973319
[ + ] Contrast enema	+ 0 -	25.3	0.2
Study: J Pediatr. 2005 Jun;146(6):787-92 PMID: 15973319
[ + ] Anorectal Manometry	+ 0 -	11.9	0.2
Study: J Pediatr. 2005 Jun;146(6):787-92 PMID: 15973319