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Sensitive Findings

Hemophagocytic Lymphohistiocytosis: Sensitivity and Specificity

Introduction: A rare disease characterized by bone marrow macrophages (histiocytes) devouring red and white blood cells. Can be caused by certain viral infections (e.g. HIV, EBV), can be inherited, or can rarely be related to malignancy (lymphoma or leukemia).

Note that a big differential diagnosis is Adult-Onset Still's disease, which can also be associated with high ferritin and even secondary HLH.

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Tags: Hematologic Tag this Diagnosis.

The sensitivity and specificity of findings for Hemophagocytic Lymphohistiocytosis are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Finding SensitivitySpecificity Comments, Study
Ferritin, high Edit 90%96%

>10,000mcg/L

Study: Pediatr Blood Cancer. 2008 Jun;50(6):1227-35. PMID: 18085676

Sensitive Findings

Finding SensitivitySpecificity Comments, Study
Decreased Glycosylated Ferritin Edit 100%76%

<26% (of total ferritin)

Study: Arthritis Rheum. 2008 May;58(5):1521-7. PMID: 18438821