GetTheDiagnosis.org

Welcome, guest.
Login or Sign up to edit.

Add an entry

Search:
 

Tools

Add a finding for this diagnosis

Add prevalence for this diagnosis

Switch to calculator mode to see positive predictive value

Switch to likelihood ratios

Sort findings by Tag

Sort findings by Differential Diagnosis

Jump To

Sensitive and Specific Findings

Sensitive Findings

Hemophagocytic Lymphohistiocytosis: Sensitivity and Specificity

Introduction: A rare disease characterized by bone marrow macrophages (histiocytes) devouring red and white blood cells. Can be caused by certain viral infections (e.g. HIV, EBV), can be inherited, or can rarely be related to malignancy (lymphoma or leukemia).

Note that a big differential diagnosis is Adult-Onset Still's disease, which can also be associated with high ferritin and even secondary HLH.

[Edit Diagnosis] [Merge dx] [Add prevalence]

Tags: Hematologic Tag this Diagnosis.

The sensitivity and specificity of findings for Hemophagocytic Lymphohistiocytosis are listed below. See the left navigation bar to change the display.

Sensitive Findings

Finding SensitivitySpecificity Comments, Study
Decreased Glycosylated Ferritin Edit 100%76%

<26% (of total ferritin)

Study: Arthritis Rheum. 2008 May;58(5):1521-7. PMID: 18438821