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Folate Deficiency: Sensitivity and Specificity

Introduction: None written.

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Tags: Metabolic Tag this Diagnosis.

The sensitivity and specificity of findings for Folate Deficiency are listed below. See the left navigation bar to change the display.

Sensitive Findings

Finding SensitivitySpecificity Comments, Study
Elevated Homocysteine Edit Sensitivity = 91%

specificity not assessed. False positives may be from: B12 deficiency, B6 deficiency, renal failure, hypovolemia, etc.

Study: Arch Intern Med. 1999 Jun 28;159(12):1289-98. PMID: 10386505

Poorly Diagnostic Findings

Finding SensitivitySpecificity Comments, Study
Low RBC Folate Edit 69%69%

B12 deficiency can cause artificially low RBC folate levels.

Study: Arch Intern Med. 1999 Jun 28;159(12):1289-98. PMID: 10386505

Elevated Methylmalonic Acid Edit Sensitivity = 12%

specificity not assessed.

Study: Arch Intern Med. 1999 Jun 28;159(12):1289-98. PMID: 10386505

Findings With Unspecified Accuracy

Finding SensitivitySpecificity Comments, Study
Low Serum Folate Edit No accuracy specified.

Rather nonspecific. Often elevated in B12 deficiency. Often depressed in alcoholics.

Study: Arch Intern Med. 1999 Jun 28;159(12):1289-98. PMID: 10386505