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Cushing's Syndrome: Sensitivity and Specificity

Introduction: i.e. hypercortisolemia. Can be primary (from an adrenal tumor or other malignancy) or secondary (from a pituitary tumor, called Cushing's Disease).

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Tags: Endocrine Tag this Diagnosis.

The sensitivity and specificity of findings for Cushing's Syndrome are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
FindingResult SensitivitySpecificity
[ + ] Decreased Libido Sensitivity = 100%
[ + ] Desmopressin Stimulation Test + 0 - 87%91%
[ + ] Dexamethasone Suppression Test + 0 - 91%87%
[ + ] Dexamethasone Suppression Test + 0 - 92%92%
[ + ] Dexamethasone Suppression Test + 0 - 93%94%
[ + ] Dexamethasone Suppression Test + 0 - 97%90%
[ + ] DHEAS + 0 - 30%79%
[ + ] Dorsal Fat Pad Sensitivity = 54%
[ + ] Ecchymoses Sensitivity = 62%
[ + ] Edema Sensitivity = 50%
[ + ] Hirsuitism Sensitivity = 81%
[ + ] Hypertension Sensitivity = 74%
[ + ] Impaired Glucose Tolerance Sensitivity = 50%
[ + ] Late-Night Plasma Cortisol + 0 - 93%20%
[ + ] Late-Night Salivary Cortisol + 0 - 92%93%
[ + ] Low-Dose Dexamethasone Suppression Test + 0 - 100%67%
[ + ] Obesity Sensitivity = 97%
[ + ] Osteopenia or Fracture Sensitivity = 50%
[ + ] Plethora Sensitivity = 94%
[ + ] Round Face Sensitivity = 88%
[ + ] Striae Sensitivity = 56%
[ + ] Urinary Free Cortisol + 0 - 94%94%