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Cryptococcal Meningitis: Sensitivity and Specificity

Introduction: Cryptococcal meningitis is caused by Cryptococcus neoformans and typically causes extremely high intracerebral pressures. Note that the serum antigen test is sensitive for AIDS patients only.

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The sensitivity and specificity of findings for Cryptococcal Meningitis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Cryptococcal Antigen in CSF + 0 - 93%93%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Cryptococcal Antigen in Serum + 0 - 99%83.3%
[ + ] Cryptococcal Antigen in Serum Sensitivity = 87%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] India Ink stain of CSF Sensitivity = 75%
[ + ] Non-contrast Head CT Sensitivity = 17%