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Poorly Diagnostic Findings

Creutzfeld Jakob Disease: Sensitivity and Specificity

Introduction: None written.

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The sensitivity and specificity of findings for Creutzfeld Jakob Disease are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Sensitive Findings
Finding	Result	Sensitivity	Specificity
[ + ] CSF 14-3-3		Sensitivity = 88%
A high level of 14-3-3 in the CSF is thought to be a marker of neuron damage. Other studies have found sensitivity as low as 53%. Specificity not assessed in these studies. Study: Brain. 2006 Sep;129(Pt 9):2278-87. PMID: 16816392 Arch Neurol 2003 Jun;60(6):813-6. PMID 12810484

Poorly Diagnostic Findings
Finding	Result	Sensitivity	Specificity
[ + ] EEG		Sensitivity = 58%
Typical findings are periodic sharp wave complexes. Specificity not assessed. Study: Brain. 2006 Sep;129(Pt 9):2278-87. PMID: 16816392
[ + ] MRI		Sensitivity = 39%
In this study, MRI findings were restricted to increased signal in the basal ganglia. Specificity not assessed. In general, another typical MRI finding is 'cortical ribboning', namely hyperintensity on DWI in some portions of the cerebral cortex. Study: Brain. 2006 Sep;129(Pt 9):2278-87. PMID: 16816392