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Colon Cancer: Sensitivity and Specificity

Introduction: None written.

[Edit Diagnosis] [Merge dx] [Add prevalence]

Tags: Gastrointestinal Problem Neoplasm Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
5%
More, Edit...

The sensitivity and specificity of findings for Colon Cancer are listed below. See the left navigation bar to change the display.

Specific Findings

Finding SensitivitySpecificity Comments, Study
Fecal Occult Blood
Duplicate Edit
5%97%

single sample from DRE

Study: Ann Intern Med. 2005 Jan 18;142(2):81-5. PMID: 15657155

Fecal Occult Blood
Duplicate Edit
24%94%

6-sample

Study: Ann Intern Med. 2005 Jan 18;142(2):81-5. PMID: 15657155

Anemia Edit 13%92%

specifically, iron-deficiency anemia

Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

Family History of Colon Cancer Edit 16%91%

Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

Rectal Mass Edit 25%89%

note that sens for abdominal mass = 4%

Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

Weight Edit 20%89%

Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

Fecal Occult Blood
Duplicate Edit
75%86%

guaiac-based test (note much higher sensitivity here compared to other studies)

Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

Sensitive Findings

Finding SensitivitySpecificity Comments, Study
Fecal Occult Blood
Duplicate Edit
95%84%

immunoassay-based test (note the very high sensitivity here)

this was only in secondary referral clinics (probable bias?)

Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

Secondary Screening Referral Guideline Edit 92%42%

At least one of the following:

  • Rectal bleeding with a change in bowel habit to looser stools and/or increased frequency of defecation persistent for 6 weeks. Age threshold: all ages.
  • Change in bowel habit as above without rectal bleeding and persistent for 6 weeks. Age threshold: over 60 years.
  • Rectal bleeding persistently without anal symptoms*. Age threshold: over 60 years.
  • A definite palpable right-sided abdominal mass. Age threshold: all ages.
  • A definite palpable rectal mass (not pelvic). Age threshold: all ages.
  • Unexplained iron deficiency anaemia. In men: below 11g/dl, all ages. In women: below 10 g/dl, post menopausal.
  • Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Age
    Duplicate Edit
    91%36%

    Age > 50

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Negative Findings

    Finding SensitivitySpecificity Comments, Study
    Diarrhea Edit 20%73%

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Constipation Edit 13%72%

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Abdominal Pain Edit 35%59%

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Poorly Diagnostic Findings

    Finding SensitivitySpecificity Comments, Study
    Age
    Duplicate Edit
    50%79%

    Age > 70

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Rectal bleeding Edit 44%66%

    for "dark blood" sens=35% / spec=85%; for "mixed with stool" sens=51% / spec=71%

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Changes in Bowel Habits Edit 52%61%

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Age
    Duplicate Edit
    83%55%

    Age > 60

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Gender Edit 62%55%

    male

    Study: BMJ. 2010 Mar 31;340:c1269 PMID: 20360221

    Findings With Unspecified Accuracy

    Finding SensitivitySpecificity Comments, Study
    S. Bovis bacteremia Edit No accuracy specified.

    Aside from colon cancer, other GI pathology, liver disease and HIV should be considered.

    Study: PMID: 16614996

    Alazmi W; Bustamante M; O'loughlin C; Gonzalez J; Raskin JB

    Dig Dis Sci. 2006 Apr;51(4):732-6.

    CEA Edit No accuracy specified.

    Carcinoembryonic antigen

    Study: no study specified.