Cleft Lip: Sensitivity and Specificity

Introduction: None written.

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The sensitivity and specificity of findings for Cleft Lip are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

MRI, prenatal

100%

In a study of 34 pregnant women, 29 of which had a facial cleft, the MRI correctly identified all anomalies without error. In addition, MRI outperformed prenatal ultrasound.

Study: Ultrasound Obstet Gynecol. 2010 Oct;36(4):445-51.

What does magnetic resonance imaging add to the prenatal ultrasound diagnosis of facial clefts?

Mailáth-Pokorny M, Worda C, Krampl-Bettelheim E, Watzinger F, Brugger PC, Prayer D.

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria. mariella.mailath-pokorny@meduniwien.ac.at

PMID: 20617504

Ultrasound, prenatal: Absence of muscle fibers crossing the lip

95%

92%

The ultrasonographer must specifically look at a frontal view to make the diagnosis

Study: Ultrasound Obstet Gynecol. 2010 Nov;36(5):596-600. doi: 10.1002/uog.7739.

Detection of lip, alveolar ridge and hard palate abnormalities using two-dimensional ultrasound enhanced with the three-dimensional reverse-face view.

Sommerlad M, Patel N, Vijayalakshmi B, Morris P, Hall P, Ahmad T, Campbell S, Lees C.

Cleft Net East, Addenbrookes Hospital, Cambridge, UK.

PMID 20617510