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Cholecystitis: Sensitivity and Specificity

Introduction: Cholecystitis is an acute infection of the gallbladder almost universally because of obstruction by gallstones (Cholelithiasis), though the entity of acalculous cystitis exists (often in the context of hypotension and shock).

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Tags: Gastrointestinal Problem Hepatic Infection Physical Exam Tag this Diagnosis.

The sensitivity and specificity of findings for Cholecystitis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Blood Test
FindingResult SensitivitySpecificity
[ + ] Elevated Alkaline Phosphatase + 0 - 45%52%
[ + ] Elevated Serum Transaminases + 0 - 38%62%
[ + ] Elevated Total Bilirubin + 0 - 45%63%
[ + ] Elevated Total Bilirubin, AST, or Alk Phos + 0 - 70%42%
[ + ] Leukocytosis + 0 - 63%57%
Combination of Tests
FindingResult SensitivitySpecificity
[ + ] Elevated Total Bilirubin, AST, and Alk Phos + 0 - 34%80%
[ + ] Elevated Total Bilirubin, AST, or Alk Phos + 0 - 70%42%
[ + ] Leukocytosis and fever + 0 - 24%85%
History
FindingResult SensitivitySpecificity
[ + ] Anorexia + 0 - 65%50%
[ + ] Emesis + 0 - 71%53%
[ + ] RUQ Pain + 0 - 81%67%
Imaging
FindingResult SensitivitySpecificity
[ + ] Abdominal CT + 0 - 91.7%99.1%
[ + ] Abdominal US + 0 - 88%80%
[ + ] HIDA scan + 0 - 97%90%
[ + ] Ultrasound No accuracy specified.
Physical Exam
FindingResult SensitivitySpecificity
[ + ] Abdominal Rigidity + 0 - 11%87%
[ + ] Guarding + 0 - 45%70%
[ + ] hearing loss + 0 - 35%80%
[ + ] Murphy sign + 0 - 65%87%
[ + ] Rebound + 0 - 30%68%
[ + ] Rectal tenderness + 0 - 8%82%
[ + ] RUQ Mass + 0 - 21%80%
[ + ] RUQ Tenderness + 0 - 77%54%
Renal
FindingResult SensitivitySpecificity
[ + ] hearing loss + 0 - 35%80%
Vital Signs
FindingResult SensitivitySpecificity
[ + ] hearing loss + 0 - 35%80%
Untagged
FindingResult SensitivitySpecificity
[ + ] Epigastric Pain No accuracy specified.