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Cholecystitis: Sensitivity and Specificity

Introduction: Cholecystitis is an acute infection of the gallbladder almost universally because of obstruction by gallstones (Cholelithiasis), though the entity of acalculous cystitis exists (often in the context of hypotension and shock).

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Tags: Gastrointestinal Problem Hepatic Infection Physical Exam Tag this Diagnosis.

The sensitivity and specificity of findings for Cholecystitis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Abdominal CT + 0 - 91.7%99.1%
[ + ] HIDA scan + 0 - 97%90%
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Murphy sign + 0 - 65%87%
[ + ] Abdominal Rigidity + 0 - 11%87%
[ + ] Leukocytosis and fever + 0 - 24%85%
Sensitive Findings
FindingResult SensitivitySpecificity
[ + ] Abdominal US + 0 - 88%80%
Negative Findings
FindingResult SensitivitySpecificity
[ + ] Abdominal Rigidity + 0 - 11%87%
[ + ] Rectal tenderness + 0 - 8%82%
[ + ] Rebound + 0 - 30%68%
[ + ] Elevated Alkaline Phosphatase + 0 - 45%52%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] hearing loss + 0 - 35%80%
[ + ] Elevated Total Bilirubin, AST, and Alk Phos + 0 - 34%80%
[ + ] RUQ Mass + 0 - 21%80%
[ + ] Guarding + 0 - 45%70%
[ + ] RUQ Pain + 0 - 81%67%
[ + ] Elevated Total Bilirubin + 0 - 45%63%
[ + ] Elevated Serum Transaminases + 0 - 38%62%
[ + ] Leukocytosis + 0 - 63%57%
[ + ] RUQ Tenderness + 0 - 77%54%
[ + ] Emesis + 0 - 71%53%
[ + ] Anorexia + 0 - 65%50%
[ + ] Elevated Total Bilirubin, AST, or Alk Phos + 0 - 70%42%
Findings With Unspecified Accuracy
FindingResult SensitivitySpecificity
[ + ] Ultrasound No accuracy specified.
[ + ] Epigastric Pain No accuracy specified.