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Celiac Sprue: Sensitivity and Specificity

Introduction: also called gluten-sensitive enteropathy and nontropical sprue.

Diagnostic algorithms outlined in UpToDate article: http://www.utdol.com/online/content/topic.do?topicKey=malsynd/2879

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Tags: Autoimmune Gastrointestinal Problem Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
No risk factors, United States 0.75% Arch Intern Med 2003 Feb 10;163(3):286-92. PMID 12578508
First-degree relatives 5% Arch Intern Med 2003 Feb 10;163(3):286-92. PMID 12578508
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The sensitivity and specificity of findings for Celiac Sprue are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Antigliadin Antibody + 0 - 94%99%
[ + ] Antiendomysial Antibody + 0 - 90%98%
[ + ] Anti-Tissue Transglutaminase + 0 - 95%94%
[ + ] Antigliadin Antibody + 0 - 85%90%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] Antigliadin Antibody + 0 - 80%82%
Findings With Unspecified Accuracy
FindingResult SensitivitySpecificity
[ + ] Small bowel biopsy No accuracy specified.
[ + ] Diarrhea No accuracy specified.