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Celiac Sprue: Sensitivity and Specificity

Introduction: also called gluten-sensitive enteropathy and nontropical sprue.

Diagnostic algorithms outlined in UpToDate article: http://www.utdol.com/online/content/topic.do?topicKey=malsynd/2879

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Tags: Autoimmune Gastrointestinal Problem Tag this Diagnosis.

Prevalence

Population / Calculator	Prevalence	Comments / Study / Link
No risk factors, United States	0.75%	Arch Intern Med 2003 Feb 10;163(3):286-92. PMID 12578508
First-degree relatives	5%	Arch Intern Med 2003 Feb 10;163(3):286-92. PMID 12578508
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The sensitivity and specificity of findings for Celiac Sprue are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Poorly Diagnostic Findings
Finding	Result	Sensitivity	Specificity
[ + ] Antigliadin Antibody	+ 0 -	80%	82%
IgG; first-generation. Study: from UpToDate: http://www.utdol.com/online/content/topic.do?topicKey=mal_synd/2879

Findings With Unspecified Accuracy
Finding	Result	Sensitivity	Specificity
[ + ] Small bowel biopsy		No accuracy specified.
need to take multiple biopsies from 2nd and 3rd portions of duodenum Study: from UpToDate: http://www.utdol.com.laneproxy/online/content/topic.do?topicKey=mal_synd/2879
[ + ] Diarrhea		No accuracy specified.
sensitivity and specificity highly variable depending on study - data in meta-analysis cited below Study: JAMA 2010 v303(17):1738