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Cardiac Amyloidosis: Sensitivity and Specificity

Introduction: Amyloidosis represents abnormal deposition of amyloid fibrils within the soft tissues. It can affect various organs, including the heart where it deposits in the myocardium. Clinical features are those of diastolic Congestive Heart Failure.

Note that the diagnosis of systemic amyloidosis can be obtained by biopsy of other involved organs (though this does not necessarily prove cardiac involvement, which has a worse prognosis).

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Tags: Cardiac Problem Hematologic Tag this Diagnosis.

The sensitivity and specificity of findings for Cardiac Amyloidosis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
Sensitive and Specific Findings
FindingResult SensitivitySpecificity
[ + ] Cardiac MRI + 0 - 88%90%
Specific Findings
FindingResult SensitivitySpecificity
[ + ] Speckled Myocardium + 0 - 26%96%
[ + ] Low ECG Voltage + 0 - 56%87%
Poorly Diagnostic Findings
FindingResult SensitivitySpecificity
[ + ] ECG + 0 - 60%64%
[ + ] Trans-Thoracic Echocardiography Sensitivity = 47%
Findings With Unspecified Accuracy
FindingResult SensitivitySpecificity
[ + ] Endomyocardial Biopsy No accuracy specified.