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Behcet Disease: Likelihood Ratios

Introduction: The following is a review article from 2009:

Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Behcet disease is a systemic inflammatory vasculitis of unknown etiology, though likely autoimmune in nature.

Areas of involvement include:

Oral ulcers

Genital ulcers

Ocular disease

Cutaneous lesions

Neurologic disease

Vascular disease

Cardiac disease

Gatrointestinal disease

Articular involvement

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Tags: Autoimmune Tag this Diagnosis.

Prevalence

Population / CalculatorPrevalence Comments / Study / Link
Turkish Population 0.08% In Turkish population betwen 80 - 420 per 100,000

Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Japanese Population 0.007% 7 - 8.5 in 10,000 in Japan

Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Norther Europe and United States 0% 0.12 to 0.64 per 100,000 in Northen Europe and United States

Behçet's disease--a contemporary review.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

PMID

19324519

More, Edit...

The likelihood ratios of findings for Behcet Disease are listed below. See the left navigation bar to change the display.

Poorly Diagnostic Findings

Finding +LR-LR Comments, Study
Genital Ulcer Edit Sensitivity = 57%

Genital ulcers occur in 57-93% of patients.

Perineal, perianal and groin lesions can occur in both sexes.

For males: Scrotum lesions are most frequent (90%) while penile lesions are infrequent.

For females: vulvar, vaginal and cervical lesions are common

Study: Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Oral ulcer Edit Sensitivity = 47%

Oral ulcers are the major manifestation of Behcet disease. They usually occur in 47-86% of patients. The oral ulcers can precede onset of other symptoms by many years. See article for description of the lesions:

Study: Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Cutaneous lesions Edit Sensitivity = 38%

Skin involvement occurs in 38-99% of patients.

Study: Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Findings With Unspecified Accuracy

Finding +LR-LR Comments, Study
Uveitis Edit No accuracy specified.

Ocular disease is commonly bilateral and tends to occur 2-3 years after onset of Bechet disease syndromes. However, it is the presenting feature in 10-20% of patients.

Study: Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Blurred Vision Edit No accuracy specified.

Part of ocular disease

Study: Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Photophobia Edit No accuracy specified.

Part of ocular disease

Study: Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519

Pathergy Edit No accuracy specified.

Sensitivity and specificity not specified

The pathergy test consists of the intradermal puncture of the skin with a 20 gauge or smaller needle 5mm obliquely into the patient's flexor aspect of the avascular forearm skin under sterile conditions and without injecting saline. The test is considered positive when an indurated erythematous small papule or pustule forms within 48 hours.

Study: Behçet's disease--a contemporary review.

Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J.

J Autoimmun. 2009 May-Jun;32(3-4):178-88. Epub 2009 Mar 26.

PMID 19324519