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Good Positive and Negative Likelihood Ratios

Good Positive Likelihood Ratio

Aspergillosis: Likelihood Ratios

Introduction: Invasive infection by the Aspergillus fungus, typically in neutropenic patients.

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Tags: Infection Pulmonary Tag this Diagnosis.

Differential Diagnoses include: Lymphoma

The likelihood ratios of findings for Aspergillosis are listed below. See the left navigation bar to change the display.

Good Positive and Negative Likelihood Ratios

Finding +LR-LR Comments, Study
Chest CT
Duplicate Edit
2.70.1

finding: pulmonary nodules

(sensitivity and specificity from different studies)

Differential Diagnosis: Lymphoma

Study: Mycoses. 2002 Oct;45(8):287-94. PMID: 12572717

Haematologica. 2000 Jul;85(7):745-52. PMID: 10897127

Clin Infect Dis. 2007 Feb 1;44(3):373-9. PMID: 17205443

Serum galactomannan assay Edit 6.50.3

the sensitivity ranged from 61 to 71 percent with a specificity of 89 to 93 percent

Study: Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis. Pfeiffer CD; Fine JP; Safdar N Clin Infect Dis. 2006 May 15;42(10):1417-727. Epub 2006 Apr 14.

PMID 16619154

Serum Beta-D-glucan Edit 5.20.3

Component of the fungal cell wall.

This study evaluated dx of invasive fungal infections, not specifically Aspergillus. The test is nonspecific and includes all fungi, including PCP (which was excluded from this study).

Study: PMID 21367728

Good Positive Likelihood Ratio

Finding +LR-LR Comments, Study
Chest CT
Duplicate Edit
220.6

For findings of 'halo sign' or 'air crescent' sign. Another study gave sensitivity for halo sign at 61%.

Study: Haematologica. 2000 Jul;85(7):745-52. PMID: 10897127

Clin Infect Dis. 2007 Feb 1;44(3):373-9. PMID: 17205443

Latex Agglutination Edit 6.30.6

Study: Haematologica. 2000 Jul;85(7):745-52. PMID: 10897127