Angioedema: Sensitivity and Specificity

Introduction: None written.

Prevalence

Patients on Enalapril

0.68%

Incidence and characteristics of angioedema associated with enalapril.

Kostis JB, Kim HJ, Rusnak J, Casale T, Kaplan A, Corren J, Levy

Arch Intern Med. 2005;165(14):1637.

PMID16043683

The sensitivity and specificity of findings for Angioedema are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Findings With Unspecified Accuracy
Finding	Result	Sensitivity	Specificity
[ + ] Hoarseness		No accuracy specified.
Study: no study specified.
[ + ] Throat tightness		No accuracy specified.
Study: no study specified.
[ + ] Swallowing difficulty		No accuracy specified.
Study: no study specified.
[ + ] Edema, non pitting		No accuracy specified.
Airway edema: face, lips, larynx Other: bowels Study: no study specified.
[ + ] Expsure to allergen		No accuracy specified.
Mast cell-mediated angioedema triggered by exposure to allergen: Begins minutes after exposure to allergen, peaks after a few hours and resolves arter 24-48 hours Associated symptoms of allergic reaction include PRURITIS, BRONCHOSPASM, THROAT TIGHTNESS and HYPOTENSION Study: no study specified.
[ + ] Exposure to Bradykinin		No accuracy specified.
- Seen with angiotensin converting enzyme (ACE) inhibitor use Not associated with urticaria, bronchospasm, or other allergic symptoms Study: no study specified.
[ + ] Colicky Pain		No accuracy specified.
- Seen in patients on ACE inhibitors and with C1 inhibitory deficiency (hereditary or acquired) Study: no study specified.