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Sensitive and Specific Findings

Specific Findings

Anaphylaxis: Sensitivity and Specificity

Introduction: None written.

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Tags: Autoimmune Tag this Diagnosis.

The sensitivity and specificity of findings for Anaphylaxis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Sensitive and Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Serum Tryptase	+ 0 -	94.1%	92.3%
tryptase > 8.23 ng/ml (cutoff of 13 ng/ml decreased sensitivity to 35% without increasing specificity) patients with a clinical allergic rxn < 6 hr in duration - anaphylaxis versus angioedema or urticaria Study: Allergy. 1999 Jun;54(6):602-6. PMID: 10435474

Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Serial Serum Tryptase	+ 0 -	73%	98%
increase > 2 mcg/l from 15 min to 60 min post exposure Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726
[ + ] Serum Tryptase	+ 0 -	55%	93%
peak tryptase > 9 mcg/l (15 min and 60 min timepoints) Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726
[ + ] Serum Tryptase	+ 0 -	36%	93%
peak tryptase > 12 mcg/l (15 and 60 min timepoints) Study: Emerg Med Australas. 2004 Apr;16(2):120-4. PMID: 15239726