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Rheumatoid Arthritis: Sensitivity and Specificity

Introduction: None written.

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Tags: Autoimmune Musculoskeletal Tag this Diagnosis.

Prevalence

Population / Calculator	Prevalence	Comments / Study / Link
argentina	1%
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The sensitivity and specificity of findings for Rheumatoid Arthritis are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Anti-CCP Antibodies	+ 0 -	67%	95%
Study: Ann Intern Med. 2007 Jun 5;146(11):797-808. PMID: 17548411

Poorly Diagnostic Findings
Finding	Result	Sensitivity	Specificity
[ + ] Rheumatoid Factor	+ 0 -	80%	80%
specificity 80-95% depending on control population (e.g. age). Sensitivity may be as low as 60% in initial stages of disease. Study: Am Fam Physician. 2002 Mar 15;65(6):1073-80. PMID: 11925083
[ + ] Elevated ESR		Sensitivity = 50%
Specificity not listed but reportedly low. Study: Am Fam Physician. 2002 Mar 15;65(6):1073-80. PMID: 11925083