Biliary Atresia: Sensitivity and Specificity

Introduction: None written.

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Tags: Hepatic Pediatrics Tag this Diagnosis.

Prevalence

Population / Calculator	Prevalence	Comments / Study / Link
Infants < 12 wk presenting with conj hyperbili	20.5%	Br J Radiol 2000 Nov;73(875):1154-8. PMID 11144791
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The sensitivity and specificity of findings for Biliary Atresia are listed below. See the left navigation bar to change the display.

Sensitive and Specific Findings

Abdominal US

90%

92.4%

gallbladder absent or irregular GB wall

infants < 12 wk with conj hyperbili

Study: Br J Radiol 2000 Nov;73(875):1154-8. PMID 11144791

Sensitive Findings

MRCP

90%

77%

another study showed sensitivity of 100% and specificity of 96% (PMID 11912518)

Study: Radiology 2002 Mar;222(3):687-91. PMID 11912518

Poorly Diagnostic Findings

HIDA scan

83%

33%

per UTD: "Pretreatment for five days with phenobarbital (5 mg/kg per day) increases the accuracy of this test by enhancing isotope excretion. The sensitivity and specificity of scintigraphy in detecting obstruction ranges from 83 to 100 percent and 33 to 100 percent respectively."

Study: UpToDate 'Approach to neonatal cholestasis' http://www.uptodate.com/online/content/topic.do?topicKey=pedi_hep/2162