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Eclampsia: Sensitivity and Specificity

Introduction: Eclampsia is defined by seizures in pregnancy. Usually patients first develop pre-eclampsia, defined by hypertension and proteinuria. Treatment of pre-eclamptic patients with magnesium helps prevent eclampsia (and also, magnesium is the most effective treatment of eclamptic seizures).

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Prevalence

Population / CalculatorPrevalence Comments / Study / Link
All Pregnancies 0.00049% BMJ 1994 Nov 26;309(6966):1395-400. PMID 7819845
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The sensitivity and specificity of findings for Eclampsia are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %. Post-Test Probability (Predictive Value): %. Switch to display mode.
**Note that calculating probabilities from more than one finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)
FindingResult SensitivitySpecificity
[ + ] Edema Sensitivity = 68%
[ + ] Epigastric Pain Sensitivity = 19%
[ + ] Headache Sensitivity = 50%
[ + ] Headache, Vision Disturbance, and Epigastric Pain Sensitivity = 4%
[ + ] Headache, Vision Disturbance, or Epigastric Pain Sensitivity = 59%
[ + ] Hypertension Sensitivity = 79%
[ + ] Proteinuria Sensitivity = 81%
[ + ] Proteinuria and Hypertension Sensitivity = 57%
[ + ] Uric Acid + 0 - 75.7%64%
[ + ] Visual Disturbances Sensitivity = 19%