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Peripheral Arterial Disease: Sensitivity and Specificity

Introduction: None written.

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Prevalence

Population / Calculator	Prevalence	Comments / Study / Link
Symptomatic adults age 60-80	15%	JAMA. 2006 Feb 1;295(5):536-46. PMID: 16449619
Asymptomatic Adults, age 60-69	5%	JAMA. 2006 Feb 1;295(5):536-46. PMID: 16449619
More populations	0%	see table 5 in JAMA. 2006 Feb 1;295(5):536-46. PMID: 16449619
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The sensitivity and specificity of findings for Peripheral Arterial Disease are listed below. See the left navigation bar to change the display.

Pre-Test Probability (Prevalence): %.	Post-Test Probability (Predictive Value): %.	Switch to display mode.
Note that calculating probabilities from more than one** finding is inherently inaccurate because findings are not independent. (For example, using two positive findings that share a common pathogenesis is likely to overestimate the true probability.)

Sensitive and Specific Findings
Finding	Result	Sensitivity	Specificity
[ + ] Ankle-Brachial Index	+ 0 -	95%	100%
Threshold < 0.9 With the patient lying supine, a sphygmomanometer cuff, placed 2 to 3 cm above the point of pulse measurement, is inflated above the systolic pressure. As the cuff pressure is slowly released, a handheld Doppler is used for obtaining the systolic pressure at the right and left ankle (either dorsalis pedis artery, posterior tibial artery, or both) and the right and left brachial artery. The systolic pressure is that pressure where the Doppler signal returns. Study: JAMA. 2006 Feb 1;295(5):536-46. PMID: 16449619
[ + ] CT angiography	+ 0 -	95%	96%
most of data from patients with intermittent claudication Study: JAMA. 2009;301(4):415-424. http://jama.ama-assn.org/cgi/content/short/301/4/415

Sensitive Findings
Finding	Result	Sensitivity	Specificity
[ + ] Skin Discoloration	+ 0 -	100%	64%
symptomatic patients Study: JAMA. 2006 Feb 1;295(5):536-46. PMID: 16449619

Poorly Diagnostic Findings
Finding	Result	Sensitivity	Specificity
[ + ] Capillary refill time	+ 0 -	35%	82%
abnormal. For moderate-severe PAD. In symptomatic patients. Study: JAMA. 2006 Feb 1;295(5):536-46. PMID: 16449619
[ + ] Palpable Pulse Abnormality	+ 0 -	66%	78%
"any palpable pulse abnormality", in a screening population Study: JAMA. 2006 Feb 1;295(5):536-46. PMID: 16449619